Anti-5-Methylcytosine antibody mouse IgM (clone 5MC-CD)
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Anti-5-Methylcytosine antibody mouse IgM (clone 5MC-CD)

Cat. No. 51-003

Store at -20°C

Size 100µg

Host Animal- Mouse 

Unlabeled 

Clone- 5MC-CD

 

 

Description 

DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. Therefore it is part of the epigenetic code and is also the most well characterized epigenetic mechanism. DNA methylation results in addition of a methyl group to DNA — for example, to the number 5 carbon of the cytosine pyrimidine ring — which involves reduction in gene expression. In adult somatic tissues, DNA methylation typically occurs in a CpG dinucleotide context; non-CpG methylation is prevalent in embryonic stem cells. This hybridoma has been constructed by Prof. H. Sano.

 

References: This product has been used in references 1-3 (& many more publications).

1. Sharif J et al “The SRA protein Np95 mediates epigenetic inheritance by recruiting Dmnt1 to methylated DNA” Nature 450: 908-912 (2007) PMID: 17994007

2. Nishiyama R et al “A chloroplast-resident DNA methyltransferase is responsible for hypermethylation of chloroplast genes in Chlamydomonas maternal gametes” PNAS 99: 5925-5930 (2002) PMID: 11983892

3. Sano H et al “Detection of heavy methylation in human repetitive DNA subsets by a monoclonal antibody against 5-methylcytosine” Biochim Biophys Acta 951:157-65 (1988) PMID: 2847796

4. Sano H et al “Identification of 5-methycytosine in DNA fragment immobilized on nitrocellulose paper “PNAS 77:3581-3585 (1980) PMID: 6251470

 

  • Item #: 51-003

Anti-5-Methylcytosine antibody mouse IgM (clone 5MC-CD)

Price: $345.00
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