Yamada, K. et al,. Clinical nephrology, Vol.42, 354-361, 1994
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Anti-AGE, Mouse-Mono (6D12), Biotin (cat. no. KH001-01)

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  • Item #: KH001-01
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Anti-AGE, Mouse-Mono (6D12), Biotin, containing 0.1% Proclin as bacteriostat
Cat. No.: KH001-01
Size: 10ug
Storage:  -20°C
Host animal: Mouse
Cross reactivity: Human
Application: ELISA, IHC, Western Blot
Biotin
Purification: APu
Clone: 6D12

Class: lgG

 

 

Reaction of protein amino groups with glucose leads, through early products such as a Schiff base and
Amadori rearrangement products, to the formation of advanced glycation end products (AGEs). Recent
immunological studies using anti-AGEs antibody (6D12) demonstrated the presence of AGEs-modified proteins
in several human tissues: (ⅰ) human lens (nondiabetic and noncataractous), (ⅱ) renal proximal tubules in
patients with diabetic nephropathy and chronic renal failure, (ⅲ) diabetic retina, (ⅳ) peripheral nerves of
diabetic neuropathy, (ⅴ) atherosclerotic lesions of arterial walls, (ⅵ)β2-microglobulin forming amyloid fibrils
in patients with hemodialysis-related amyloidosis, (ⅶ) senile plaques of patients with Alzheimer’s disease, (ⅷ)
the peritoneum of CAPD patients, (ⅸ) skin elastin in actinic elastosis, and (ⅹ) ceriod/lipofuscin deposits. These
results suggest a potential role of AGEs-modification in normal aging as well as age-enhanced disease processes.
This antibody named as 6D12 has been used to demonstrate AGEs-modified proteins in these human tissues,
indicating potential usefulness of this antibody for histochemical identification and biochemical quantification of
AGEs-modified proteins.
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