Anti-Autotaxin, Rabbit-Poly <Anti-ENPP2> (Cat. No. KM106)

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  • Item #: KM106
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Anti-Autotaxin, Rabbit-Poly <Anti-ENPP2>

Cat. No. KM106

Store at -20°C

Size 25µg

Antigen- Zebrafish 

Host Animal- Rabbit

Cross Reactivity- Rat

Application- Western Blot

Unlabeled 

Purification- APu

 

 

Description

Autotaxin, a member of the ENPP (Ectonucleotide pyrophospatase/phosphodiesterase) family of ectoenzymes, was originally identified as a motogen secreted by a melanoma cell line and subsequently reported to promote cell proliferation, cell motility, angiogenesis, and neurite retraction. Autotaxin has lysophospholipase D activity and appears to exert its effects by generation of the lipid mediator lysophosphatidic acid (LPA) from lysophosphatidylcholine and sphingosine 1-phosphate (S1P) from sphingosylphosphorylcholine (SPC) outside the cell. Autotaxin levels are significantly higher in cancerous tissues than in normal tissues, suggesting that this novel extracellular protein may be involved in tumor progression. 

 

References 

1. Koike S. et al.: The N-terminal hydrophobic sequence of autotaxin (ENPP2) functions as a signal peptide. Genes Cells. 2006 Feb;11(2):133-42.

2. Sato K. et al.: Identification of autotaxin as a neurite retraction-inducing factor of PC12 cells in cerebrospinal fluid and its possible sources. J Neurochem. 2005 Feb;92(4):904-14.

3. Tanaka M. et al.: Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma. FEBS Lett. 2004 Jul 30;571(1-3):197-204.

4. Stefan C. et al.: NPP-type ectophosphodiesterases: unity in diversity. Trends Biochem Sci. 2005 Oct;30(10):542-50. 

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