Anti-Dnmt3b antibody, affinity-purified (rabbit polyclonal)
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Anti-Dnmt3b antibody, affinity-purified (rabbit polyclonal)

Price: $375.00
  • Item #: 70-206
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Anti-Dnmt3b antibody, affinity-purified (rabbit polyclonal), ChIP grade

Cat. No. 70-206

Store at -20°C

Size 100µg

Host Animal- Rabbit

Unlabeled 

Purification- APu

 

 

Description 

Dnmt3b (DNA (cytosine-5-)-methyltransferase 3b) has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues (epigenetics). Dnmt3b is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facialanomalies (ICF) syndrome. 

 

References: This antibody was used for Western blotting and immunohistochemistry in Ref. 2~4.

1. Rhee I et al “DNMT1 and DNMT3b cooperate to silence genes in human cancer cells” Nature 416: 552-6 (2002) PMID: 11932749

2. Aoki A et al “Enzymatic properties of de novo-type mouse DNA (cytosine-5) methyltransferases” Nucleic Acids Research 29: 3506-3512 (2001) PMID: 11522819

3. Watanabe D et al “Stage- and cell-specific expression of Dnmt3a and Dnmt3b during embryogenesis” Mechanisms of Development 118: 187-190 (2002) PMID: 12351185

4. Sakai Y et al “Co-expression of de novo DNA methyltransferases Dnmt3a2 and Dnmt3L in gonocytes of mouse embryos” Gene ExpressionPatterns 5: 231-237 (2004) PMID: 15567719

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