Anti-GPR120,Mouse-Mono (2B6) (Cat. No. KG138)
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Anti-GPR120,Mouse-Mono (2B6) (Cat. No. KG138)

Price: $635.00
  • Item #: KG138
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Anti-GPR120,Mouse-Mono (2B6)
Cat. No. KG138
Store at -20°C
Size 25µg
Host Animal- Mouse
Cross Reactivity- Human 
Application- FCM, IC
Unlabeled 
Clone- 2B6

 

 

Description

GPR120 is a member of G protein-coupled receptor (GPCR) family and functions as a specific receptor for unsaturated long-chain free fatty acids (FFAs) such as palmitoleic acid, α-linolenic acid, docosahexaenoic acid. The expression of GPR120 is widely detected in various tissues, and GPR120 is highly expressed in the pituitary, lung, small intestine, colon, and adipose tissues. It has been shown that the stimulation of GPR120 by FFAs promotes the secretion of GLP-1, known as the most potent insulinotropic incretin, from the gastrointestinal tract. It has been also demonstrated that FFAs stimulate the ERK and PI3K-Akt pathways through GPR120 and lead to anti-apoptotic effect in enteroendocrine cell line, and that GPR120 regulates adipogenic process such as adipocyte development and differentiation. In addition, a study suggested that GPR120 is expressed in the taste bud cells in circumvallate papillae to sense dietary fat. This antibody is specific to GPR120 and will be useful for research on diabetes, obesity.

 

References 

1. Gotoh C. et al.:The regulation of adipogenesis through GPR120.

2. Matsumura S. et al.: GPR expression in the rat taste bud relating to fatty acid sensing.

3. Katsuma S. et al.: Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1.

4. Hirasawa A. et al. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.

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