Anti-GPR40, Mouse-Mono (G16)
Click To Enlarge

Anti-GPR40, Mouse-Mono (G16)

Price: $692.00
  • Item #: KG116
* Marked fields are required.
Qty: *

Anti-GPR40, Mouse-Mono (G16)
Cat. No. KG116
Store at -20°C
Size 25µg
Antigen- Mouse
Host Animal- Mouse
Cross Reactivity- Human/ Mouse
Application- FCM, IC, IHC, IP, Western Blot 
Unlabeled 
Purification- APu
Clone- G16
Class- IgG

 

 

Description 

G protein coupled receptors (GPCRs) are a protein family of transmembrane receptors, and involved in a wide variety of physiological processes. GPR40 is also a member of GPCRs and functions as a receptor for long-chain free fatty acids (FFA), which is expressed in beta cells in the islets of pancreas and is involved in the regulation of glucose and lipid metabolisms. Long chain FFAs amplify glucose-stimulated insulin secretion from pancreatic beta cells by activating GPR40. GPR40 knockout mice fed a high-fat diet are protected against obesity-induced hyperinsulinemia and hepatic steatosis. Transgenic mice overexpressed GPR40 in pancreatic beta cells had impaired beta cell function and developed diabetes.GPR40 is an important mediator of both the acute, stimulatory effects and chronic, deleterious effects of FFAs on beta cells. Moreover, GPR40 may be implicated in the control of breast cancer cell growth by fatty acids and provide a link between fat and cancer. This antibody is specific to GPR40 and will be useful to research for lipid metabolism, obesity and diabetes.

 

References 

1. Briscoe CP. et al: The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem. 2003 Mar 28;278(13):11303-11.

2. Itoh Y. et al: Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature. 2003 Mar 13;422(6928):173-6. Epub 2003 Feb 23.

3. Steneberg P. et al: The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab. 2005 Apr;1(4):245-58.

4. Hardy S. et al: Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40. J Biol Chem. 2005 Apr 8;280(14):13285-91.

5.Hirasawa A. et al: Production and characterization of a monoclonal antibody against GPR40 (FFAR1; free fatty acid receptor 1) BBRC 365 (2008) 22‐28

Reviews (0) Write a Review
No Reviews. Write a Review