Anti-HCV NS5a protein antibody, mouse monoclonal (8926)
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Anti-HCV NS5a protein antibody, mouse monoclonal (8926)

Price: $375.00
  • Item #: 65-062
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Anti-HCV NS5a protein antibody, mouse monoclonal (8926)
Cat. No. 65-062
Store at -20°C
Size- 100µg
Host Animal- Mouse
Unlabeled 
Clone- 8926

 

 

Description 

Hepatitis C virus (HCV) is a small (55-65 nm in size), enveloped, positive sense single-stranded RNA virus in the family Flaviviridae and the principal cause of parenteral non-A, non-B hepatitis. The virus genome consists of a single open reading frame of approximately 9,400 bases which encodes a single polyprotein of about 3,010 amino acids (1, 2, 3). The polyprotein is processed by host cell and viral proteases into four structural proteins (core, envelope1 and 2, and p7) and six non-structural proteins (NS2, 3, 4a, 4b, 5a, and 5b) necessary for viral replication. The primary function of NS5a is not known, but from the comparative studies with other viruses it is predicted to play a role in RNA replication. 

 

References 

1. Choo, Q-L. et al. (1989) “Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244, 359-362 PMID: 2523562

2. Kato,N. et al. (1990) “Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis.” Proc. Natl. Acad. Sci. USA 87, 9524-9528 PMID: 2175903

3. Takamizawa, A. et al. (1991) “Structure and organization of the hepatitis C virus genome isolated from human carriers.” J.Virol.65, 1105-1113 PMID: 1847440

4. Manabe,S. et al. (1994) “Production of nonstructural proteins of hepatitis C virus requires a putative viral protease encoded by N3.” Virology 198, 636-644 PMID: 8291245

*This antibody is produced and used in ref.4

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