Anti-HP1γ/CBX3 antibody (rabbit), ChIP grade (Cat. No. 70-225)
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Anti-HP1γ/CBX3 antibody (rabbit), ChIP grade (Cat. No. 70-225)

Price: $279.00
  • Item #: 70-225
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Anti-HP1γ/CBX3 antibody (rabbit), ChIP grade

Cat. No. 70-225

Store at -20°C

Size 50µg

Host Animal Rabbit 

Unlabeled 

 

 

Description 

Heterochromatin protein 1 (HP1) is a major component of heterochromatin which plays a role in assembly of various proteins on chromatin and gene silencing. The HP1 family is evolutionally conserved, with members in fungi, plants and animals but not prokaryotes, and there are multiple members within the same species. The HP1 family proteins are encoded by a class of genes known as the chromobox (CBX) genes. In humans, HP1γ is encoded by the Chromobox homolog 3 (CBX3) gene. HP1γ has been observed to interact directly or indirectly with several non-histone proteins with a wide variety of functions (Ref 1). The product is prepared by immunizing rabbit with the synthetic peptide WHSCPEDEAQ-C corresponding to the C-terminal sequence of human HP1γ (Ref 2, 3) and purified by affinity purification with the peptide. 

 

References: This product was used in references 2 and 3.

1. Lomberk G et al “The Heterochromatin Protein 1 family” Genome Biol 7: 228 Review (2006) PMID: 17224041

2. Kametaka A et al “Interaction of the chromatin compactioninducing domain (LR domain) of Ki-67 antigen with HP1 proteins” Genes Cells 7: 1231-1242 (2002) PMID: 12485163

3. Wang F et al “The assembly and maintenance of heterochromatin initiated by transgene repeats are independent of the RNA interference pathway in mammalian cells” Mol Cell Biol 26: 4028-4040 (2006) PMID: 16705157

 

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