Anti-KOR, Mouse-Mono (5E3) (Cat. No. KG139)
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Anti-KOR, Mouse-Mono (5E3) (Cat. No. KG139)

Price: $635.00
  • Item #: KG139
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Anti-KOR, Mouse-Mono (5E3)
Cat. No. KG139
Store at -20°C
Size 25µg
Host Animal- Mouse 
Cross Reactivity- Human 
Application- FCM, IP, IC, Western Blot
Unlabeled 
Clone- 5E3


 

Description 

OPRK1 (opioid receptor, kappa 1), also known as KOR, belongs to the rhodopsin subfamily of G-protein-coupled receptor (GPCR) family. OPRK1 is consist of 380 amino acids and is widely expressed in the nervous system. OPRK1 is activated by endogenous opioid peptide agonists derived from prodynorphin. Stimulation of OPRK1 in vivo produces many effects, including analgesia, water diuresis, dysphoria, antipruritic effects, and attenuation of cocaine craving in addicts. In addition, some studies reported that OPRK1 is associated with alcohol intake and the risk for alcohol dependence and activation of OPRK1 in human microglia suppresses HIV-1 expression.

 

References

1. Simonin F. et al.: kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, function expression, pharmacology, and expression pattern in the central nervous system

2. Chao CC. et al.: kappa opioid receptors in human microglia downregulate human immunodeficiency virus 1 expression.

3. Edenberg HJ. et al.:A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence.

4. Simonin F. et al. Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal.

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