Anti-MEF, Human, Rabbit-Poly (Cat. No. KK053)
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Anti-MEF, Human, Rabbit-Poly (Cat. No. KK053)

Price: $565.00
  • Item #: KK053
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Anti-MEF, Human, Rabbit-Poly
Cat. No. KK053
Store at -20°C
Size- 10µg
Antigen- Human 
Host Animal- Rabbit 
Cross Reactivity- Human 
Application- Western Blot 
Purification- APu



The ETS transcription factor family plays a key role in cell growth and differentiation, especially in several malignant and genetic disorders. Recently, it has discovered that MEF(Myeloid ELF-1-like Factor) may compete with ETS-2 for binding to the ets-binding sites on the promoters of the MMP and IL8 which is involved in tumor malignancy. So that, MEF is expected as a candidate of tumor suppressor. In addition, not like another tumor suppression factor such as p53, MEF is a novel tumor suppressor gene that is located on the X chromosome. This antibody is very useful for analyzing the MEF expression level in the cell. 

1. Seki Y, Suico MA, Uto A, Hisatsune A, Shuto T, Isohama Y, Kai H. :The ETS transcription factor MEF is a candidate tumor suppressor gene on the X chromosome. Cancer Res. 2002 Nov 15; 62(22):6579-86.
2. Suico MA, Koyanagi T, Ise S, Lu Z, Hisatsune A, Seki Y, Shuto T, Isohama Y, Miyata T, Kai H. :Functional dissection of the ETS transcription factor MEF. Biochim Biophys Acta. 2002 Aug 19;1577(1):113-20.
3. Hisatsune A, Uto A, Koyanagi T, Chihara T, Miyata T, Basbaum C, Kai H. : [Novel transcription factor MEF is associated with the function of lung epithelial cells] Nippon Yakurigaku Zasshi. 1999 Oct;114 Suppl 1:81P-85P. Japanese.
4. Kai H, Hisatsune A, Chihara T, Uto A, Kokusho A, Miyata T, Basbaum C.: Myeloid ELF-1-like factor up-regulates lysozyme transcription in epithelial cells. J Biol Chem. 1999 Jul 16;274(29):20098-102. 
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