Anti-Nestin antibody. rat monoclonal(7A3) (Cat. No. 73-100)
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Anti-Nestin antibody. rat monoclonal(7A3) (Cat. No. 73-100)

Price: $288.00
  • Item #: 73-100
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Anti-Nestin antibody. rat monoclonal(7A3)

Cat. No. 73-100

Store at -20°C

Size 100µg

Host Animal- Rat 

Unlabeled 

Clone- 7A3

 

 

Description 

Nestin is an intermediate filament protein that is expressed in stem cells and progenitor cells in the mammalian central nervous system (CNS) during development. Nestin is replaced in the adult organism by other intermediate filament proteins, however, it may be re-expressed under certain pathological conditions such as ischemia, inflammation, brain injury, and neoplastic transformation. Nestin has been detected in many kinds of tumors, especially in tumors derived from the CNS, therefore it is considered to be a marker for cancer stem cells in neurogenic tumors. The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes. 

 

References

1. Hockfield S & McKay RD "Identification of major cell classes in the developing mammalian nervous system" J Neurosci 5: 3310-3328 (1985) PMID: 4078630

2. Gilyarov AV “Nestin in central nervous system cells” Neuroscience and Behavioral Physiology 38:165-169 (2008) PMID: 18197384

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