Anti-OAT2, Human, Rabbit-Poly (Cat. No. KE031)
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Anti-Organic Anion Transporter 2, Human, Rabbit-Poly <Anti-OAT2>
Cat. No. KE031
Store at -20°C
Size- 25µg
Antigen- Human 
Host Animal- Rabbit 
Cross Reactivity- Human 
Application- IHC 
Unlabeled 
Purification- APu

 

Description 

To eliminate the drug, xenobiotics, a varirety of endogeneous substances, and their metabolites out of the body, specific membrane proteins named transporters are required. There are two major pathways for the elimination, hepatic one through bile and renal one to urine. The transporter fall into various transport systems by the transportative substrate. In particular, oraganic ion transporter family is comprised of organic anion transport family (OAT), oraganic cation transport family (OCT), OCTN/carnitine transport family, and OAT are multispecific organic anion transpoters, the substrates of which include a lot of both endogeneous and exogeneous anions . Organic anion transporter 2 (OAT2) is predicted 12 putative membrane-spanning protein, and which is expressed predominantly in the liver and only weakly in the kidney. OAT2 mediates the Na+ -independent transport of organic anions, such as salicylate, and also mediates the transport of prostaglandin E2 (PGE2), methotrexate, acetylsalicylate and PAH (ρ-aminohippurate). This has been proved to be useful for immunohistochemistry . 

 

References 

1. Sekine T., Cha S.H., Tsuda M., Apiwattanakul N., Nakajima N., Kanai Y., Endou H.:Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Letters 429 .179-182, 1998

2. Sekine T., Cha S.H., Kanai Y.and Endou H.:Molecular biology of multispecific organic anion transporter family (OAT family). Clin.Exp.Nephlrol.3.237-243, 1999

3. Sekine T., Cha S.H.and Endou H.:The multispecific organic anion transporter (OAT) family. pflugers Arch-Eur.J.Physiol.440.337-350,2000

  • Item #: KE031

Anti-OAT2, Human, Rabbit-Poly (Cat. No. KE031)

Price: $565.00
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