Anti-Opioid Receptor, δ1, Mouse-Mono (1E7) <Anti-DOR>
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Anti-Opioid Receptor, δ1, Mouse-Mono (1E7) <Anti-DOR>

Price: $635.00
  • Item #: KG142
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Anti-Opioid Receptor, δ1, Mouse-Mono (1E7) <Anti-DOR>
Cat. No. KG142
Store at -20°C
Size 25µg
Host Animanl- Mouse 
Cross Reactivity- Human 
Application- FCM, IC, IP, Western Blot 
Unlabeled 
Clone- 1E7

 

 

Description

OPRD1 (opioid receptor, delta 1), also known as DOR, belongs to the rhodopsin subfamily of G-protein-coupled receptor (GPCR) family. OPRD1 is consist of 372 amino acids and is located largely in the brain, active T cells. OPRD1 may be responsible for analgesia, dysphoria, immunopotentiation Activation of native T cells markedly up-regulates the expression of OPRD1 and OPRD1 modulates T cell proliferation, IL-2 production, chemotaxis, and intracellular signaling. Stimulating OPRD1 expressed by activated CD4+ T cells significantly suppresses the expression of HIV-1. In addition, it has been showed that activation of OPRD1 is neuroprotective against severe stress, such as hypoxia-, glutamate-induced cell injury.

 

References 

1. Kieffer BL. et al.: The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):12048-52.

2. Sharp BM. et al.: Immunofluorescence detection of delta opioid receptors (DOR) on human peripheral blood CD4+ T cells and DOR-dependent suppression of HIV-1 expression.  J Immunol.  2001 Jul 15;167(2):1097-102.

3. Ma MC. et al.: Oxygen-sensitive {delta}-opioid receptor-regulated survival and death signals: novel insights into neuronal preconditioning and protection. J Biol Chem. 2005 Apr 22;280(16):16208-18. Epub 2005 Feb 1. 

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