Anti-Organic Anion Transporter 3, Rat, Rabbit-Poly <Anti-OAT3>
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Anti-Organic Anion Transporter 3, Rat, Rabbit-Poly <Anti-OAT3>

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  • Item #: KE035
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Anti-Organic Anion Transporter 3, Rat, Rabbit-Poly <Anti-OAT3>
Cat. No. KE035
Store at -20°C
Size- 25µg
Antigen- Rat 
Host Animal- Rabbit 
Cross Reactivity- Rat 
Application- IHC, Western Blot 
Unlabeled 
Purification- APu

 

 

Description 

To eliminate the drug, xenobiotics, a varirety of endogeneous substances, and their metabolites out of the body, specific membrane proteins named transporters are required. There are two major pathways for the elimination, one of which is hepatic one through bile, and another is renal one to urine. The transporter fall into various transport systems by the transportative substrate. In particular, oraganic ion transporter family is comprised of organic anion transport family (OAT), oraganic cation transport family (OCT), OCTN/carnitine transport family, and OAT are multispecific organic anion transpoters, the substrates of which include a lot of both endogeneous and exogeneous anions. Rat organic anion transporter 3 (OAT3) encodes a 536 amino acid residue protein, of which molecular weight is 130kDa. OAT3 is expressed in the kidney, liver, brain, and eye. OAT3 mediated the uptake of organic anions, such as PAH (ρ-aminohippurate), ochratoxin A and estrone sulfate, cimetidine, and prostaglandin E2. This antidody has been proved to be useful for immunohistochemistry.  

 

References 

1. Kusuhara H., Sekine T., Utsunomiya-Tate N., Tsuda M., Kojima R., Cha S.H., Sugiyama., Kanai Y.and Endou H.:Molecular cloning and characterization of new multispecific organic anion transporter from rat brain. J.Biol.Chem.274 (19) 13675-13680, 1999

2. Sekine T., Cha S.H., Kanai Y.and Endou H.:Molecular biology of multispecific organic anion transporter family (OAT family). Clin.Exp.Nephlrol.3.237-243,1999

3. Sekine T., Cha S.H.and Endou H.:The multispecific organic anion transporter (OAT) family. pflugers Arch-Eur.J.Physiol.440.337-350,2000

4. Kojima R., Sekine T., Kawachi M., Cha S.H., Suzuki Y. and Endou H.: Immunolocalization of Multispecific Organic Anion Transporters, OAT1, OAT2, and OAT3 in Rat Kidney. J.Am.Soc.Nephrol. in press  

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