Anti-Pentosidine Monoclonal Antibody Peroxidase conjugated
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Anti-Pentosidine Monoclonal Antibody Peroxidase conjugated

Price: $808.00
  • Item #: KH012-02
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Anti-Pentosidine Monoclonal Antibody (Clone No. PEN-12) Peroxidase conjugated
Cat. No. KH012-02
Store at -20°C
Size- 50µg
Host Animal- Mouse 
Application- IHC, Western Blot 
Label- HRP
Purification- APu
Clone- PEN-12 
Class- IgG

 

 

Description

Reaction of protein amino groups with glucose leads, through the early products such as a Schiff base and Amadori rearrangement products, to the formation of advanced glycation end products (AGEs). Recent immunological studies using anti-AGEs antibody (6D12) demonstrated the presence of AGEs-modified proteins in several human tissues: (ⅰ) human lens (nondiabetic and noncataractous), (ⅱ) renal proximal tubules in patients with diabetic nephropathy and chronic renal failure, (ⅲ) diabetic retina, (ⅳ) peripheral nerves of diabetic neuropathy, ( ⅴ ) atherosclerotic lesions of arterial walls, ( ⅵ ) β 2-microglobulin forming amyloid fibrils in patients with hemodialysis-related amyloidosis, (ⅶ) senile plaques of patients with Alzheimer’s disease, (ⅷ) the peritoneum of CAPD patients, (ⅸ) skin elastin in actinic elastosis, and (ⅹ) ceriod / lipofuscin deposits. These results suggest a potential role of AGEs-modification in normal aging as well as age-enhanced disease processes. This antibody named as 6D12 has been used to demonstrate AGEs-modified proteins in these human tissues, indicating potential usefulness of this antibody for histochemical identification and biochemical quantification of AGEs-modified proteins. Pentosidine is one of the Maillard compounds identified by Monnier et al in 1989. It has been proved to cross-link Arginine to Lysine residue and be detected in β 2-microglobulin from patients with hemodialysis- related amyloidosis. 

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