Anti-Prion protein antibody mouse monoclonal (7A1)
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Anti-Prion protein antibody mouse monoclonal (7A1)

Price: $288.00
  • Item #: 65-903
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Anti-Prion protein antibody mouse monoclonal (7A1)
Cat. No. 65-903 
Store at -20°C
Size- 50µg
Host Animal- Mouse 
Unlabeled 
Clone- 7A1 

 

 

Description 

Prion protein PrP is a membrane glycosylphosphatidylinositol(GPI) anchored glycoprotein highly expressed in neuron and glia cells as well as immune and reproductive cells. Mutations in the octapeptide repeat regions as well as elsewhere in this gene have been associated with neurodegenerative diseases such as Creutzfeldt Jakob disease, fatal familial insomnia, Gerstmann Straussler disease, Huntington disease like 1, and kuru. The infectious isoform of PrPC, known as PrPSc, is able to convert normal PrPP C proteins into the infectious isoform, which is insoluble amyloid aggregate, by changing their conformation (1). Mature PrP protein in human consists of 209 amino acids. Several topological forms exist; one cell surface form anchored via glycolipid and two transmembrane forms, which are responsible for appearance of multiple bands in SDS-PAGE (Figure).

 

References 

1. Sakudo A et al ”GPI-anchorless human prion protein is secreted and glycosylated but lacks superoxide dismutase activity” Int J Mol Med 21: 217-222 (2008) PMID: 18204788 

*This antibody has been used in Ref.1 

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